Aldose reductase in relation to diabetes-induced embryopathy in rats
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Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat
Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabe...
متن کاملAldose reductase, diabetes, and thickening of the retinal inner limiting membrane.
Capillary basement membrane thickening is typical of the diabetic retina, and aldose reductase appears to be involved since a diabetic-like thickening can be induced by galactose feeding and prevented with aldose reductase inhibitors. Because aldose reductase is present in the Mueller's cells, studies were undertaken to determine if thickening of the retinal inner limiting membrane, which is th...
متن کاملInhibitory Activity of Flavonoids on the Lens Aldose Reductase of Healthy and Diabetic Rats
Aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. Inhibition of the activity of this enzyme can prevent cataract in diabetic patients’ lenses. In this study the inhibitory effect of two flavonoids, quercetin and naringin, in the activity of aldose reductase in streptozotocin-induced diabetic and healthy rats were investigated. Thirty ...
متن کاملNerve microvessel changes in diabetes are prevented by aldose reductase inhibition.
BACKGROUND Despite the potential importance of endoneurial microvessel abnormalities in diabetic neuropathy, the pathogenesis of these abnormalities is incompletely understood. We wished to evaluate the effect of experimental diabetes on endoneurial microvessels and determine if an aldose reductase inhibitor alters any of the changes induced by diabetes. METHODS We compared streptozocin diabe...
متن کاملA selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.
Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding selectivity, in vivo potency, and human safety; as a result, the pathogenic role of aldose reductase in diabetic retinopathy remains controversial. ARI-809 is a recently discovered aldose reductase inhibitor (ARI) ...
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